Journal article
Shared genetic contribution to ischemic stroke and Alzheimer's disease
M Traylor, P Adib-Samii, D Harold, M Dichgans, J Williams, CM Lewis, HS Markus, M Fornage, EG Holliday, P Sharma, JC Bis, BM Psaty, S Seshadri, MA Nalls, WJ Devan, G Boncoraglio, R Malik, BD Mitchell, SJ Kittner, MA Ikram Show all
Annals of Neurology | WILEY-BLACKWELL | Published : 2016
DOI: 10.1002/ana.24621
Open access
Abstract
Objective Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. Methods Using genome-wide association study (GWAS) data from METASTROKE + (15,916 IS cases and 68,826 controls) and the International Genomics of Alzheimer's Project (IGAP; 17,008 AD cases and 37,154 controls), we evaluated known associations with AD and IS. On the subset of data for which we could obtain compatible genotype-level data (4,610 IS cases, 1,281 AD cases, and 14,320 controls), we estimated the genome-wide genetic correlation (rG) between AD and IS, and the three..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by the Stroke Association (TSA 2013/01 and TSA 2010/10; to H.S.M. & M.T.), the MRC/Stroke Association (Clinical Training Fellowship; to P.A.-S.), the National Institute for Health Research (NIHR) (Senior Investigator Award; to H.S.M.), the Wellcome Trust (Collection of the UK Young Lacunar Stroke DNA Study [WT072952]; to H.S.M); the NIHR Comprehensive Biomedical Research Unit at Cambridge University Hospitals Trust (to H.S.M.); the NIHR Mental Health Biomedical Research Center at South London and Maudsley NHS Foundation Trust and King's College London (to C.M.L.); and the NIHR Biomedical Research Center based at Guy's and St Thomas' NHS Foundation Trust and King's College London (to C.M.L.). Additional sources of support are provided in the Supplementary Materials.