Bone mineral density in prepubertal asthmatics receiving corticosteroid treatment.
M Harris, S Hauser, TV Nguyen, PJ Kelly, C Rodda, J Morton, N Freezer, BJ Strauss, JA Eisman, JL Walker
J Paediatr Child Health | Published : 2001
OBJECTIVE: To examine whether bone mass is reduced in prepubertal, asthmatics receiving high doses of inhaled corticosteroids. METHODOLOGY: A cross-sectional comparison of lumbar spine-bone mineral density (LS-BMD) was undertaken in 76 subjects after stratifying them according to dosage and administration route of corticosteroid. RESULTS: Weight was the only independent predictor of LS-BMD (r(2) = 0.38). Children receiving greater than 800 microg/day of inhaled corticosteroid plus intermittent oral corticosteroid had a significantly lower weight-adjusted LS-BMD than children treated with 400-800 microg/day of inhaled corticosteroid (mean difference: 0.06 g/cm(2), 95% confidence interval (CI)..View full abstract