Journal article

Synergy Between Adiposity, Insulin Resistance, Metabolic Risk Factors, and Inflammation in Adolescents

Rae-Chi Huang, Trevor A Mori, Valerie Burke, John Newnham, Fiona J Stanley, Louis I Landau, Garth E Kendall, Wendy H Oddy, Lawrence J Beilin

DIABETES CARE | AMER DIABETES ASSOC | Published : 2009

Abstract

OBJECTIVE: The purpose of this study was to investigate relationships between inflammatory markers and components of a metabolic syndrome cluster in adolescents. RESEARCH DESIGN AND METHODS: This was a cross-sectional analysis of an Australian childhood cohort (n = 1,377) aged 14 years. Cluster analysis defined a "high-risk" group similar to adults with metabolic syndrome. Relevant measures were anthropometry, fasting insulin, glucose, lipids, inflammatory markers, liver function, and blood pressure. RESULTS: Of the children, 29% fell into a high-risk metabolic cluster group compared with 2% by a pediatric metabolic syndrome definition. Relative to the "low-risk" cluster, they had higher BMI..

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Grants

Funding Acknowledgements

We acknowledge the support of the Raine Medical Foundation, Healthway, Western Australia, the Telethon Institute of Child Research (University of Western Australia), and the Australian National Health and Medical Research Council (NHMRC). R.C.H. is supported by the NHMRC Centre for Training in Clinical Cardiovascular and Cerebrovascular Research (Royal Perth Hospital) and by Athelstan and Amy Saw scholarships.No potential conflicts of interest relevant to this article were reported.We are grateful to all the families who took part in this study and the Raine Study team, which includes data collectors, cohort managers, data managers, clerical staff, research scientists, and volunteers.