Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Xinwei Ge; Aleksandr Kakinen; Esteban N Gurzov; Wen Yang; Lokman Pang; Emily H Pilkington; Praveen Govindan-Nedumpully; Pengyu Chen; Frances Separovic; Thomas P Davis; Pu Chun Ke; Feng Ding

Journal article

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Xinwei Ge, Aleksandr Kakinen, Esteban N Gurzov, Wen Yang, Lokman Pang, Emily H Pilkington, Praveen Govindan-Nedumpully, Pengyu Chen, Frances Separovic, Thomas P Davis, Pu Chun Ke, Feng Ding

Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2017

DOI: 10.1039/c7cc04291d

University of Melbourne Researchers

Frances Separovic Author Chemistry

Emily Pilkington Author Microbiology and Immunology

Grants

Awarded by ARC

Awarded by NSF CAREER

Awarded by NIH

Awarded by NHMRC

Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Funding Acknowledgements

The work is partially supported by ARC Project No. CE140100036 (Davis), NSF CAREER CBET-1553945 (Ding), NIH R35GM119691 (Ding), NHMRC Project Grant APP1071350 (Gurzov), and an internal grant from Monash Institute of Pharmaceutical Sciences (Ke). Gurzov is supported by a Juvenile Diabetes Research Foundation (JDRF) fellowship. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH and NSF.