Journal article

Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs

CJ Hawkey, JA Karrasch, L Szczepanski, DG Walker, A Barkun, AJ Swannell, ND Yeomans

New England Journal of Medicine | MASS MEDICAL SOC | Published : 1998


BACKGROUND: Misoprostol is effective for ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and abdominal pain. We compared the efficacy of omeprazole and misoprostol in healing and preventing ulcers associated with NSAIDs. METHODS: In a double-blind study, we randomly assigned 935 patients who required continuous NSAID therapy and who had ulcers or more than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg of omeprazole orally in the morning or 200 microg of misoprostol orally four times daily. Patients were treated for four weeks or, in the absence of healing, eight weeks. Treatment succ..

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University of Melbourne Researchers