Journal article

A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs

ND Yeomans, Z Tulassay, L Juhasz, I Racz, JM Howard, CJ van Rensburg, AJ Swannell, CJ Hawkey

New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 1998


BACKGROUND: Suppressing acid secretion is thought o reduce the risk of ulcers associated with regular use of nonsteroidal antiinflammatory drugs (NSAIDs), but the best means of accomplishing this is uncertain. METHODS: We studied 541 patients who required continuous treatment with NSAIDs and who had ulcers or more than 10 erosions in either the stomach or duodenum. Patients were randomly assigned to double-blind treatment with omeprazole, 20 mg or 40 mg orally per day, or ranitidine, 150 mg orally twice a day, for four or eight weeks, depending on when treatment was successful (defined as the resolution of ulcer and the presence of fewer than five erosions in the stomach, and fewer than five..

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University of Melbourne Researchers