Journal article

ETHANOL IMPAIRS BILIARY LYSOSOMAL-ENZYME RELEASE IN RATS

RB SEWELL, SA GRINPUKEL, ND YEOMANS

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1986

Abstract

The effects of ethanol on hepatic lysosomes are poorly documented. This study examined the biliary release of lysosomal enzymes, a marker of the hepatocyte-to-bile excretory pathway, after ethanol administration in the isolated perfused rat liver model. At concentrations similar to those reached in human plasma during social drinking, ethanol markedly decreased biliary lysosomal enzyme output and bile flow in the rat. Ethanol did not affect hepatic activities or the release into perfusate of lysosomal and other subcellular marker enzymes. Hence, ethanol may potentially inhibit hepatocyte-to-bile excretion of other compounds processed through lysosomes.

University of Melbourne Researchers