Journal article

Modafinil decreases cocaine choice in human cocaine smokers only when the response requirement and the alternative reinforcer magnitude are large

Richard W Foltin, Margaret Haney, Gillinder Bedi, Suzette M Evans

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

Abstract

This study examined how response effort (pressing a keyboard button) for cocaine and the value of an alternative reinforcer (opportunity to play a game of chance for money) combined with 'free' cocaine (with no response effort) affected cocaine choice when participants were maintained on modafinil or placebo. Nontreatment-seeking current cocaine smokers were enrolled in a placebo-controlled, double-blind, within-subject study comprising both inpatient and outpatient phases. Participants were maintained on placebo capsules (0mg/day) during one inpatient phase and modafinil (300mg/day) capsules during another inpatient phase in counter-balanced order. A minimum of 8 medication-free days separa..

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University of Melbourne Researchers

Grants

Awarded by National Institute on Drug Abuse


Awarded by Columbia University Medical Center's CTSA grant from NCATS-NCRR/NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE ON DRUG ABUSE


Funding Acknowledgements

This research was supported by DA-021319 from the National Institute on Drug Abuse, and approved by the New York State Psychiatric Institute Internal Review Board. The research was supported in part by Columbia University Medical Center's CTSA grant no. UL1 RR024156 from NCATS-NCRR/NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The expert. medical and nursing assistance of Eric Rubin, M.D., Alicia Couraud R.N. and Audrey Perez R.N., and the assistance of Malgortata Zawodna, Ashley Soh and Madeleine Finkel is gratefully acknowledged.