Journal article
Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
SM Laws, S Gaskin, A Woodfield, V Srikanth, D Bruce, PE Fraser, T Porter, P Newsholme, N Wijesekara, S Burnham, V Doré, QX Li, P Maruff, CL Masters, S Rainey-Smith, CC Rowe, O Salvado, VL Villemagne, RN Martins, G Verdile
Scientific Reports | NATURE PORTFOLIO | Published : 2017
Open access
Abstract
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer's disease (AD) pathological features. However, the association of T2D with pathological and clinical phenotypes in humans is unclear. Here we investigate the relationship of indices of IR (HOMA-IR) and pancreatic β-cell function (HOMA-B) with cognitive performance across several domains (Verbal/Visual Episodic Memory, Executive Function, Language and a measure of Global cognition) and AD biomarkers (CSF Aβ42, T-tau/P-tau, hippocampal volume..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Funding for the AIBL study was provided in part by the study partners [Commonwealth Scientific Industrial and research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, CogState Ltd.]. The AIBL study has also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health - funded through the CRC Program (Grant ID: 20100104), an Australian Government Initiative. GV is supported by the Curtin Senior Resarch Fellowship (CRF140196), West Australian Department of Health Merit Award and the National Health and Medical Research Council (APP1105698) awarded to G.V, P.N., P.F. and R.M. We thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD. We kindly thank all AIBL Research Group members (http://aibl.csiro.au/about/aibl-research-team/).