Journal article

"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

Anne-Noel Samaha, Philip Seeman, Jane Stewart, Heshmat Rajabi, Shitij Kapur

Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2007

DOI: 10.1523/JNEUROSCI.5416-06.2007

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Keywords

Schizophrenia
Dopamine
Striatum
Animals
In-Vivo
Infusion Pumps, Implantable
High-Affinity Receptors
Supersensitivity
Dopamine D-2 Receptors
D2-Dopamine Receptor Occupancy
Behavioral Supersensitivity
Nucleus-Accumbens
Science & Technology
Clozapine
Vacuous Chewing Movements
Avoidance Learning
Protein Binding
Male
Antipsychotic Agents
Life Sciences & Biomedicine
Chronic Haloperidol Treatment
Rats
Antipsychotics
Super-Sensitivity Psychosis
Treatment Failure
Time Factors
Schizophrenic-Patients
Rats, Sprague-Dawley
Neurosciences
Neurosciences & Neurology
Rat
Nucleus Accumbens
Receptors, Dopamine D2