First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

HS Wasan; P Gibbs; NK Sharma; J Taieb; V Heinemann; J Ricke; M Peeters; M Findlay; A Weaver; J Mills; C Wilson; R Adams; A Francis; J Moschandreas; PS Virdee; P Dutton; S Love; V Gebski; A Gray; A Bateman; C Blesing; E Brown; I Chau; S Cummins; D Cunningham; S Falk; M Hadaki; M Hall; T Hickish; J Hornbuckle; F Lofts; S Lowndes; A Mayer; M Metcalfe; G Middleton; A Montazeri; R Muirhead; A Polychronis; C Purcell; P Ross; RA Sharma; L Sherwin; D Smith; R Soomal; D Swinson; A Walther; G Wilson; P Amin; B Angelelli; J Balosso; A Beny; D Bloomgarden; E Boucher; HR Bruch; J Bui; M Burge; G Cardaci; J Carlisle; S Chai; YJ Chen; P Chevallier; M Chuong; S Clarke; A Coveler; M Craninx; T Delanoit; A Deleporte; P Eliadis; F Facchini; T Ferguson; M Ferrante; G Frenette; J Frick; V Ganju; M Garofalo; K Geboes; G Gehbauer; B George; R Geva; M Gordon; K Gregory; S Gulec; J Hannigan; G van Hazel; N Heching; T Helmberger; A Hendlisz; K Hendrickx; M Holtzman; R Isaacs; C Jackson; P James; A Kaiser; C Karapetis; A Kaubisch; YD Ko; H Kröning; F Lammert; W Liauw; S Limentani

Journal article

First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

HS Wasan, P Gibbs, NK Sharma, J Taieb, V Heinemann, J Ricke, M Peeters, M Findlay, A Weaver, J Mills, C Wilson, R Adams, A Francis, J Moschandreas, PS Virdee, P Dutton, S Love, V Gebski, A Gray, A Bateman Show all

Lancet Oncology | Published : 2017

DOI: 10.1016/S1470-2045(17)30457-6

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Abstract

Background Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases. The studies were designed for combined analysis of overall survival. Methods FOXFIRE, SIRFLOX, and FOXFIRE-Global were randomised, phase 3 trials done in hospitals and specialist liver centres in 14 countries worldwide ..

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