Journal article
Impaired bone and muscle development in young people treated with antiepileptic drugs
PJ Simm, S Seah, A Gorelik, L Gilbert, J Nuguid, GA Werther, MT Mackay, JL Freeman, SJ Petty, JD Wark
Epilepsia | WILEY | Published : 2017
DOI: 10.1111/epi.13893
Abstract
Objective: Antiepileptic drugs (AEDs) are associated with reduced bone density, balance impairment, and increased fracture risk in adults. However, pediatric data are limited. Therefore, we aimed to examine bone, muscle, and balance outcomes in young patients taking AEDs. Methods: We undertook a case–control study utilizing an AED exposure–discordant matched-pair approach. Subjects were aged 5–18 years with at least 12 months of AED exposure. Pairs were twins, nontwin siblings and first cousins, sex- and age-matched (to within 2 years), allowing for greater power than with unrelated control subjects. Dual energy x-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT), ..
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Funding Acknowledgements
We would like to thank the Neurology team at RCH and the staff at the Australian Twin Registry for assistance in sourcing potential subjects. Twins Research Australia receives support from the National Health and Medical Research Council through a Centre of Research Excellence Grant, which is administered by the University of Melbourne. We are also extremely grateful to the families and young people who gave up their time to be part of this project.