Journal article
Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c
G Liu, MA Cooley, PM Nair, C Donovan, AC Hsu, AG Jarnicki, TJ Haw, NG Hansbro, Q Ge, AC Brown, H Tay, PS Foster, PA Wark, JC Horvat, JE Bourke, CL Grainge, WS Argraves, BG Oliver, DA Knight, JK Burgess Show all
Journal of Pathology | WILEY | Published : 2017
DOI: 10.1002/path.4979
Abstract
Asthma is a chronic inflammatory disease of the airways. It is characterized by allergic airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma patients, in particular those with chronic or severe asthma, have airway remodelling that is associated with the accumulation of extracellular matrix (ECM) proteins, such as collagens. Fibulin-1 (Fbln1) is an important ECM protein that stabilizes collagen and other ECM proteins. The level of Fbln1c, one of the four Fbln1 variants, which predominates in both humans and mice, is increased in the serum and airways fluids in asthma but its function is unclear. We show that the level of Fbln1c was increased in the lungs of m..
View full abstractGrants
Funding Acknowledgements
We thank the staffs of the animal facilities of the University of Newcastle and Hunter Medical Research Institute. PMH is supported by a National Health and Medical Research Council (NHMRC) Principal Research Fellowship, and a Brawn Fellowship from the Faculty of Health and Medicine, The University of Newcastle. This work was supported by NHMRC grants to PMH. JKB is supported by a Rosalind Franklin Fellowship co-funded by the University of Groningen and the European Union.