Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study
Teresa M MacDonald, Lisa Hui, Stephen Tong, Alice J Robinson, Kirsten M Dane, Anna L Middleton, Susan P Walker
BMC MEDICINE | BMC | Published : 2017
BACKGROUND: While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of stillbirths occur in appropriate-for-gestational-age (AGA, > 10th centile) fetuses. AGA fetuses are plausibly also at risk of stillbirth if placental insufficiency is present. Such fetuses may be expected to demonstrate declining growth trajectory across pregnancy, although they do not fall below the 10th centile before birth. We investigated whether reduced growth velocity in AGA fetuses is associated with antenatal, intrapartum and neonatal indicators of placental insufficiency. METHODS: We performed a prospective cohort study of 308 nulliparous women who subsequen..View full abstract
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Awarded by NHMRC
NHMRC Grant #1065854 to SW; Australian Government Research Training Program Scholarship to TM; Mercy Health Foundation philanthropic funding for purchase of the COSMED PEA POD air displacement plethysmography device. Funding sources had no involvement in study design, collection or analysis of data, or in the writing or submission of this manuscript.