Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation
Ali Zaid, Jyh Liang Hor, Susan N Christo, Joanna R Groom, William R Heath, Laura K Mackay, Scott N Mueller
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2017
Infection or inflammation of the skin recruits effector CD8+ T cells that enter the epidermis and form populations of long-lived tissue-resident memory T (TRM) cells. These skin TRM cells migrate within the constrained epidermal environment by extending multiple dynamic dendritic projections and squeezing between keratinocytes to survey the tissue for pathogens. In this study, we examined the signals required for this distinctive mode of T cell migration by inhibiting key cytoskeletal components and performing intravital two-photon microscopy to visualize TRM cell behavior. We found that TRM cell motility and dendrite formation required an intact actomyosin cytoskeleton and the Rho-associate..View full abstract
This work was supported by the National Health and Medical Research Council of Australia.