Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats

C de Ávila; S Chometton; C Lenglos; J Calvez; AL Gundlach; E Timofeeva

Journal article

Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats

C de Ávila, S Chometton, C Lenglos, J Calvez, AL Gundlach, E Timofeeva

Behavioural Brain Research | ELSEVIER SCIENCE BV | Published : 2018

DOI: 10.1016/j.bbr.2017.08.044

Abstract

The neuropeptide relaxin-3 (RLN3) binds with high affinity to its cognate receptor, relaxin-family peptide receptor 3 (RXFP3), and with lower affinity to RXFP1, the cognate receptor for relaxin. Intracerebroventricular (icv) administration of RLN3 in rats strongly increases food and water intake and alters the activity of the hypothalamic-pituitary-adrenal (HPA) and gonadal (HPG) axes, but the relative involvement of RXFP3 and RXFP1 in these effects is not known. Therefore, the effects of icv administration of equimolar (1.1 nmol) amounts of RLN3 and the RXFP3-selective agonist RXFP3-A2 on food and water intake, plasma levels of corticosterone, testosterone, and oxytocin and c-fos mRNA expre..

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Andrew Gundlach Author

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Funding Acknowledgements

This work was financially supported by the Natural Sciences and Engineering Research Council of Canada (E.T.; grant 1295926), Canadian Institutes of Health Research (E.T.; grant 126123), and National Health and Medical Research Council of Australia (A.L.G.; grant 1067522). We thank Genevieve Guevremont for valuable technical assistance.