External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules

GM Haeusler; KA Thursky; MA Slavin; F Mechinaud; FE Babl; P Bryant; R De Abreu Lourenco; R Phillips

Journal article

External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules

GM Haeusler, KA Thursky, MA Slavin, F Mechinaud, FE Babl, P Bryant, R De Abreu Lourenco, R Phillips

Pediatric Infectious Disease Journal | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

DOI: 10.1097/INF.0000000000001777

Abstract

Background: Fever and neutropenia (FN) clinical decision rules (CDRs) are recommended to help distinguish children with cancer at high and low risk of severe infection. The aim of this study was to validate existing pediatric FN CDRs designed to stratify children with cancer at high or low risk of serious infection or medical complication. Methods: Pediatric CDRs suitable for validation were identified from a literature search. Relevant data were extracted from an existing data set of 650 retrospective FN episodes in children with cancer. The sensitivity and specificity of each of the CDR were compared with the derivation studies to assess reproducibility. Results: Six CDRs were identified f..

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University of Melbourne Researchers

Kas Thursky Author

Monica Slavin Author

Franz Babl Author

Penelope Bryant Author

Grants

Awarded by Royal Children's Hospital Foundation

Funding Acknowledgements

G.M.H. was supported by a National Health and Medical Research Council postgraduate scholarship (GNT1056158). F.E.B. was partly funded by a grant from the Royal Children's Hospital Foundation, Melbourne, Australia, and an NHMRC Practitioner Fellowship. R.P. was funded by a Post-Doctoral Research Fellow grant from the NIHR (UK) Grant number PDF-10872.