Journal article

Maternal vitamin D and offspring trabecular bone score

NK Hyde, SL Brennan-Olsen, JD Wark, SM Hosking, KL Holloway, JA Pasco



No studies have explored the relationship with maternal vitamin D (25(OH)D) in pregnancy and offspring trabecular bone score (TBS). Our data suggest that maternal 25(OH)D in early pregnancy, but not late, may be associated with offspring TBS in boys. These data act as hypothesis-generating findings for confirmation in larger, longer-term studies. INTRODUCTION: Trabecular bone score (TBS), a novel tool derived from dual-energy X-ray absorptiometry (DXA), reflects the microarchitecture of the vertebrae. It has been shown to predict fracture independent of standard DXA parameters in adult populations. Previously, we demonstrated that maternal serum 25-hydroxyvitamin D (25(OH)D) during pregnancy..

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Awarded by NHMRC

Funding Acknowledgements

The authors wish to thank the participants for their ongoing participation in the Vitamin D in Pregnancy Study. Further thanks are extended to the study personnel, both past and present. The initial phases of VIP were funded by a project grant from the National Health and Medical Research Council (NHMRC) of Australia. The Bupa Foundation provided funding for the 11-year follow-up. N.K.H. is supported by an Australian Postgraduate Award, S.L.B.-O. is supported by a Career Development Fellowship from the NHMRC (1107510) and K.L.H. is supported by an Alfred Deakin Postdoctoral Fellowship.