Journal article
Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry
S Frost, L Robinson, CC Rowe, D Ames, CL Masters, K Taddei, SR Rainey-Smith, RN Martins, Y Kanagasingam
Journal of Ophthalmology | HINDAWI LTD | Published : 2017
DOI: 10.1155/2017/7935406
Abstract
Cortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N=14) and cognitively normal healthy control (HC, N=115) participants, with the HC group stratified according to high (N=38) and low (N=77) neocortical amyloid burden (NAB). Constriction ..
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Awarded by Hollywood Private Hospital Research Foundation
Funding Acknowledgements
The authors wish to thank the Australian Imaging, Biomarker and Lifestyle (AIBL) Study Team (http://www.aibl.csiro.au/about/aibl-research-team) for referring participants to the study. They also wish to thank the participants of the AIBL study for their commitment and dedication in helping advance research into the early detection and causation of AD. Funding for the study was provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), the Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study also received funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC2), the Cooperative Research Centre (CRC) for Mental Health-funded through the CRC program (an Australian Government Initiative, Grant ID 20100104), the McCusker Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria. Shaun Frost received funding support from the National Health and Medical Research Council (NHMRC) of Australia, in the form of a Dementia Research Fellowship.