Journal article

Hepatitis B among immigrants from Myanmar: Genotypes and their clinical relevance

Thomas R Schulz, Rosalind Edwards, M Christine Thurnheer, Lilly Yuen, Margaret Littlejohn, Peter Revill, Melissa Chu, Firuz Tanyeri, Amanda Wade, Beverley-Ann Biggs, Joseph Sasadeusz

Journal of Medical Virology | WILEY | Published : 2018

Abstract

Hepatitis B virus (HBV) from 76 adult immigrants in Australia from Myanmar was characterized to determine the prevalence of different HBV genotypes and subgenotypes. A mutational analysis was then performed to determine the presence of clinically significant mutations and correlate them to clinical outcomes. Initial genotyping revealed 68 patients with genotype C (89.5%) and eight patients with genotype B (10.5%). Phylogenetic analysis revealed the large majority of the genotype C infections were of subgenotype C1 (67/68). Sequencing of the HBV polymerase gene (and overlapping surface gene) revealed no mutations associated with antiviral resistance. HBV surface gene mutations were detected i..

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