Journal article

Levels of messenger ribonucleic acid for cytochrome P450 17 alpha-hydroxylase and P450 aromatase in preovulatory bovine follicles decrease after the luteinizing hormone surge.

AK Voss, JE Fortune

Endocrinology | Published : 1993


During the transition from the follicular to the luteal phase, follicular steroid secretion shifts from predominantly 17 beta-estradiol and androgen production before the LH surge to decreased androgen and estrogen and increased progesterone production after the LH surge. Our objective was to determine if changes in 17 beta-estradiol and androgen production by the preovulatory follicle are effected via changes in mRNA levels for the steroidogenic enzymes cytochrome P450 17 alpha-hydroxylase/C17, C20-lyase (P450-17 alpha) and cytochrome P450 aromatase (P450arom). Heifers were injected with prostaglandin F2 alpha (PGF2 alpha) during the luteal phase to initiate luteolysis and a follicular phas..

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University of Melbourne Researchers