Journal article

Guidelines for diagnosis and management of aphthous stomatitis.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Monica Nunziata, Silvia Piccolo, Nicola Cirillo

Pediatr Infect Dis J | Published : 2007


Aphthous ulcers are the most common oral mucosal lesions in the general population. These often are recurrent and periodic lesions that cause clinically significant morbidity. Many suggestions have been proposed but the etiology of recurrent aphthous stomatitis (RAS) is unknown. Several precipitating factors for aphthous ulcers appear to operate in subjects with genetic predisposition. An autoimmune or hypersensitivity mechanism is widely considered possible. Sometimes aphthous ulcers can be the sign of systemic diseases, so it is essential to establish a correct diagnosis to determine suitable therapy. Before initiating medications for aphthous lesions, clinicians should determine whether w..

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University of Melbourne Researchers