Journal article

Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin

Nour Nicolas, Julie A Muir, Susan Hayward, Justin L Chen, Peter G Stanton, Paul Gregorevic, David M de Kretser, Kate L Loveland, Sudhanshu Bhushan, Andreas Meinhardt, Monika Fijak, Mark P Hedger

REPRODUCTION | BIOSCIENTIFICA LTD | Published : 2017

Abstract

Experimental autoimmune orchitis (EAO) is a rodent model of chronic testicular inflammation that mimics the pathology observed in some types of human infertility. In a previous study, testicular expression of the inflammatory/immunoregulatory cytokine, activin A, was elevated in adult mice during the onset of EAO, indicating a potential role in the regulation of the disease. Consequently, we examined the development of EAO in mice with elevated levels of follistatin, an endogenous activin antagonist, as a potential therapeutic approach to testicular inflammation. Prior to EAO induction, mice received a single intramuscular injection of a non-replicative recombinant adeno-associated viral vec..

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University of Melbourne Researchers

Grants

Awarded by Monash University to the International Research Training Group between Justus Liebig University of Giessen and Monash University, Melbourne


Funding Acknowledgements

This work was performed with the support of the Deutsche Forschungsgemeinschaft (D F G) and Monash University to the International Research Training Group between Justus Liebig University of Giessen and Monash University, Melbourne (G R K 1871/1) on 'Molecular pathogenesis on male reproductive disorders'. This study was also supported by grants from the National Health and Medical Research Council of Australia (to M P H, D M de K and K L L) and the Victorian Government's Operational Infrastructure Support Programme.