Journal article

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8 T cell response magnitude

Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017

Abstract

TNF is a pro-inflammatory cytokine produced by both lymphoid and non-lymphoid cells. As a consequence of the widespread expression of its receptors (TNFR1 and 2), TNF plays a role in many important biological processes. In the context of influenza A virus (IAV) infection, TNF has variably been implicated in mediating immunopathology as well as suppression of the immune response. Although a number of cell types are able to produce TNF, the ability of CD8+ T cells to produce TNF following viral infection is a hallmark of their effector function. As such, the regulation and role of CD8+ T cell-derived TNF following viral infection is of great interest. Here, we show that the biphasic production..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This work was supported by Australian National Health and Medical Research Council (NHMRC) funding (APP1071916). and a Sylvia and Charles Viertel Senior Medical Research Fellowship awarded to N.L.L.G.This work was supported by Australian National Health and Medical Research Council (NHMRC) funding (APP1071916). and a Sylvia and Charles Viertel Senior Medical Research Fellowship awarded to N.L.L.G.