Journal article
Peptide receptor radionuclide therapy (PRRT) in European Neuroendocrine Tumour Society (ENETS) grade 3 (G3) neuroendocrine neoplasia (NEN) - a single-institution retrospective analysis
SP Thang, MS Lung, G Kong, MS Hofman, J Callahan, M Michael, RJ Hicks
European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2018
Abstract
Purpose: Grade 3 NENs are aggressive tumours with poor prognosis. PRRT+/− radiosensitising chemotherapy is a potential treatment for disease with high somatostatin receptor (SSTR) expression without spatially discordant FDG-avid disease. We retrospectively evaluated the efficacy of PRRT in G3 NEN. Methods: Kaplan–Meier estimation was used to determine progression-free survival (PFS) and overall survival (OS) defined from start of PRRT. Subgroup analysis was performed for patients with Ki-67 ≤ 55% and >55%. Anatomical response (RECIST 1.1) and toxicity 3 months after PRRT was determined. Disease control rate (DCR) was defined as complete response (CR), partial response (PR) and stable disease..
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Funding Acknowledgements
Professor Hicks' research is supported by a National Health and Medical Research Council of Australia Program grant and practitioner fellowship. We thank our radiopharmacists and radiochemists for their excellent support of our theranostics program and our dedicated nuclear medicine technologists and nursing staff for the care of our patients. Finally, we are grateful for the trust invested in us by our patients, their families and their managing clinicians.