Journal article

Bridging Bio-Nano Science and Cancer Nanomedicine

Mattias Bjornmalm, Kristofer J Thurecht, Michael Michael, Andrew M Scott, Frank Caruso

ACS NANO | AMER CHEMICAL SOC | Published : 2017

Abstract

The interface of bio-nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core concepts of the field-e.g., the enhanced permeability and retention (EPR) effect, tumor targeting and accumulation, and even the purpose of "nano" in cancer medicine-are hotly debated. In parallel, considerable advances in neighboring fields are occurring rapidly, including the recent progress of "immuno-oncology" and the fundamental impact it is having on our understanding and the clinical treatment of the group of diseases collectively known as cancer. Herein, we (i) revisit how cancer is commonly treated in the clinic and how this relates to nanomedicine; (ii) ..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by ARC Centre of Excellence in Convergent Bio Nano Science and Technology


Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This research was supported by the Australian Research Council (ARC) under the Australian Laureate Fellowship scheme (FL120100030), and the ARC Centre of Excellence in Convergent Bio Nano Science and Technology (Project No. CE140100036); the National Health and Medical Research Council (NHMRC) under the NHMRC Senior Practitioner Fellowship scheme (No. 1084178); and by the Victorian Government through an Infrastructure support program. We thank Alison E. Burke and Cassio Lynm for assistance with preparing Figure 1, and Matthew Faria, Paul Van de Ven, and Martin Bjornmalm for critical reading of the manuscript and valuable discussions.