DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging
Belinda Phipson, Alicia Oshlack
Genome Biology | BMC | Published : 2014
Awarded by NHMRC grant
We thank Jovana Maksimovic who downloaded and provided R code for pre-processing the kidney cancer and aging dataset, assisted in downloading the prostate and lung cancer datasets, provided valuable advice on the analysis of methylation data, as well as providing feedback on the paper. We thank Gordon Smyth for his insightful discussion on Levene's test. We thank Patrick Molloy for performing initial analysis related to this work. We thank Ian Majewski for providing helpful insights on the manuscript. We thank Oliver Sieber and Chris Love for helpful discussion surrounding cancer epigenetics and the biological relevance of differential variability in methylation data. We acknowledge the TCGA Research Network as well as the specimen donors and the research groups involved for making the data publicly available. The research was done with the support of NHMRC grant APP1051402. AO is a career development fellow of the NHMRC APP1051481.