Journal article
Segmental duplications contribute to gene expression differences between humans and chimpanzees
R Blekhman, A Oshlack, Y Gilad
Genetics | GENETICS SOCIETY AMERICA | Published : 2009
Abstract
In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees. Copyright © 2009 by the Genetics Society of America.
Grants
Awarded by National Institute of General Medical Sciences
Funding Acknowledgements
We thank G. Perry, L. Barreiro, R. Bainer, and C. Cain for helpful discussions and J. Marioni, Z. Gauhar, and N. Zeus for comments on the manuscript. This work was supported by the Sloan Foundation and National Institutes of Health grant GN4077959 to Y.G.