Journal article
Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism
BR Brown, EJ Lee, PE Snow, EE Vance, Y Iwakura, N Ohno, N Miura, X Lin, GD Brown, CA Wells, JR Smith, RR Caspi, HL Rosenzweig
Clinical and Experimental Immunology | WILEY | Published : 2017
DOI: 10.1111/cei.13021
Abstract
Uveitis (intraocular inflammation) is a leading cause of loss of vision. Although its aetiology is largely speculative, it is thought to arise from complex genetic–environmental interactions that break immune tolerance to generate eye-specific autoreactive T cells. Experimental autoimmune uveitis (EAU), induced by immunization with the ocular antigen, interphotoreceptor retinoid binding protein (IRBP), in combination with mycobacteria-containing complete Freund's adjuvant (CFA), has many clinical and histopathological features of human posterior uveitis. Studies in EAU have focused on defining pathogenic CD4+ T cell effector responses, such as those of T helper type 17 (Th17) cells, but the ..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors thank Dr Ruth J. Napier (VA Portland Health Care System and School of Medicine, Oregon Health and Science University, Portland, OR, USA), with Dr Tiffany Hughes and Anthony Smith (Immunology, Allergy and Arthritis, Flinders University School of Medicine), for their helpful discussions. We are also grateful to Rachel Penchoen-Lin at VA Portland Health Care System for her technical contributions. This work was supported by National Institutes of Health (RO1 EY025250) and Intramural funding (NEI Project no. EY00184), with Department of Veterans Affairs Biomedical Laboratory Research and Development Service (Merit Review Award I01 BX002180) and the Australian Research Council (F130101648).