Journal article

Clinical review of 24-35 year olds conceived with and without in vitro fertilization: study protocol

Sharon Lewis, Joanne Kennedy, David Burgner, Robert McLachlan, Sarath Ranganathan, Karin Hammarberg, Richard Saffery, David J Amor, Michael MH Cheung, Lex W Doyle, Markus Juonala, Susan Donath, John McBain, Jane Halliday

REPRODUCTIVE HEALTH | BMC | Published : 2017

Abstract

BACKGROUND: Children conceived by assisted reproductive technologies (ART) currently comprise 4% of Australian births. The manipulation of biological parameters related to fertilization and implantation are integral to successful ART but potentially pose a risk to the longer-term health of the offspring. There is consensus that many common adult health problems (particularly cardiovascular, metabolic and respiratory conditions) have their origins in early life, possibly before birth, and that risk trajectories track through childhood until clinical disease manifests in adulthood. Early life epigenetic variation may play a role in this process. However little is known about the long-term heal..

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