Journal article
Multiple P450s and Variation in Neuronal Genes Underpins the Response to the Insecticide Imidacloprid in a Population of Drosophila melanogaster
S Denecke, R Fusetto, F Martelli, A Giang, P Battlay, A Fournier-Level, RA O'Hair, P Batterham
Scientific Reports | NATURE PORTFOLIO | Published : 2017
Open access
Abstract
Insecticide resistance is an economically important example of evolution in response to intense selection pressure. Here, the genetics of resistance to the neonicotinoid insecticide imidacloprid is explored using the Drosophila Genetic Reference Panel, a collection of inbred Drosophila melanogaster genotypes derived from a single population in North Carolina. Imidacloprid resistance varied substantially among genotypes, and more resistant genotypes tended to show increased capacity to metabolize and excrete imidacloprid. Variation in resistance level was then associated with genomic and transcriptomic variation, implicating several candidate genes involved in central nervous system function ..
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Funding Acknowledgements
The authors would like to thank the University of Melbourne for the Writing Up Scholarship and the Melbourne International Research Scholarship that assisted in financing this work. Furthermore, we must acknowledge Hang Nuoc Bao Hang for assisting in larvae picking. Llewellyn Green and Trent Perry also contributed productive discussions on the topic matter. Lastly, we must thank Michael Murray of the University of Melbourne for providing fly facilities during the renovations of our own flyroom.