Journal article

Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype

Harindra Jayasekara, Dallas R English, Andrew Haydon, Allison M Hodge, Brigid M Lynch, Christophe Rosty, Elizabeth J Williamson, Mark Clendenning, Melissa C Southey, Mark A Jenkins, Robin Room, John L Hopper, Roger L Milne, Daniel D Buchanan, Graham G Giles, Robert J MacInnis



The influence of lifestyle factors on survival following a diagnosis of colorectal cancer (CRC) is not well established. We examined associations between lifestyle factors measured before diagnosis and CRC survival. The Melbourne Collaborative Cohort Study collected data on alcohol intake, cigarette smoking and physical activity, and body measurements at baseline (1990-1994) and wave 2 (2003-2007). We included participants diagnosed to 31 August 2015 with incident stages I-III CRC within 10-years post exposure assessment. Information on tumor characteristics and vital status was obtained. Tumor DNA was tested for microsatellite instability (MSI) and somatic mutations in oncogenes BRAF (V600E..

View full abstract


Awarded by National Health and Medical Research Council

Funding Acknowledgements

Victorian Health Promotion Foundation; Grant sponsor: National Health and Medical Research Council; Grant number: 209057; 251553; 504711; Grant sponsor: Cancer Council Victoria; Grant sponsor: B.M.L. is supported by a Fellowship from the National Breast Cancer Foundation. M.A.J. is an NHMRC Senior Research Fellow. J.L.H. is a NHMRC Senior Principal Research Fellow. D.D.B. is a University of Melbourne Research at Melbourne Accelerator Program (R@MAP) Senior Research Fellow and a NHMRC R.D. Wright Biomedical Career Development Fellow. RR's position was funded by the Foundation for Alcohol Research and Education. The funding sources played no role in the study design, in the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the article for publication.