Journal article

Neural correlates of working memory in children and adolescents with agenesis of the corpus callosum: An fMRI study

V Siffredi, MM Spencer-Smith, P Barrouillet, MJ Vaessen, RJ Leventer, V Anderson, P Vuilleumier

Neuropsychologia | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

The ability to temporarily maintain relevant information in mind in the presence of interference or distracting information, also called working memory (WM), is critical for higher cognitive functions and cognitive development. In typically developing (TD) children, WM is underpinned by a fronto-parietal network of interacting left and right brain regions. Developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation resulting from disruption of corpus callosum formation. This study aims to investigate functional organisation of WM in children and adolescents with AgCC using functional magnetic resonance imaging (fMRI). Nine children with AgCC and a compar..

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Grants

Awarded by Geneva Academic Society


Awarded by Swiss National Science Foundation Doc. CH scholarship


Awarded by Australian National Health and Medical Research Council Senior Practitioner Fellowship


Funding Acknowledgements

This study was supported by Victorian Government's Operational Infrastructure Support Program, the Murdoch Children's Research Institute and the Alain Patry Grant from the Geneva Academic Society (2014/45). VS was supported by the Swiss National Science Foundation Doc. CH scholarship (P0GEP1_149041). VA was supported by Australian National Health and Medical Research Council Senior Practitioner Fellowship (1079478).