Journal article

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development

Kjeld Mollgard, Katarzyna M Dziegielewska, Camilla B Holst, Mark D Habgood, Norman R Saunders

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Adult brain is protected from entry of drugs and toxins by specific mechanisms such as ABC (ATP-binding Cassette) efflux transporters. Little is known when these appear in human brain during development. Cellular distribution of three main ABC transporters (ABCC1, ABCG2, ABCB1) was determined at blood-brain barriers and interfaces in human embryos and fetuses in first half of gestation. Antibodies against claudin-5 and -11 and antibodies to α-fetoprotein were used to describe morphological and functional aspects of brain barriers. First exchange interfaces to be established, probably at 4-5 weeks post conception, are between brain and embryonic cerebrospinal fluid (eCSF) and between outer su..

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