Journal article

Development of drug-loaded polymer microcapsules for treatment of epilepsy

Yu Chen, Qi Gu, Zhilian Yue, Jeremy M Crook, Simon E Moulton, Mark J Cook, Gordon G Wallace

Biomaterials Science | ROYAL SOC CHEMISTRY | Published : 2017

Abstract

Despite significant progress in developing new drugs for seizure control, epilepsy still affects 1% of the global population and is drug-resistant in more than 30% of cases. To improve the therapeutic efficacy of epilepsy medication, a promising approach is to deliver anti-epilepsy drugs directly to affected brain areas using local drug delivery systems. The drug delivery systems must meet a number of criteria, including high drug loading efficiency, biodegradability, neuro-cytocompatibility and predictable drug release profiles. Here we report the development of fibre- and sphere-based microcapsules that exhibit controllable uniform morphologies and drug release profiles as predicted by mat..

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Grants

Awarded by Australian Research Council Centre of Excellence Scheme


Awarded by ARC


Funding Acknowledgements

Funding from the Australian Research Council Centre of Excellence Scheme (Project Number CE 140100012) is gratefully acknowledged. GGW is grateful to the ARC for support under the Australian Laureate Fellowship scheme (FL110100196). The authors are grateful to UCB Pharma for continued support. The authors gratefully acknowledge Mr Tony Romeo and Mr Mitchell Nancarrow from Electron Microscope Centre (EMC) for technical assistance of SEM images statistical analysis. The authors also gratefully acknowledge the use of facilities within the Australian National Fabrication Facility (ANFF).