Journal article

Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei in sudden infant death syndrome related to prematurity and sex

Fiona M Bright, Robert Vink, Roger W Byard, Jhodie R Duncan, Henry F Krous, David S Paterson



Sudden infant death syndrome (SIDS) involves failure of arousal to potentially life threatening events, including hypoxia, during sleep. While neuronal dysfunction and abnormalities in neurotransmitter systems within the medulla oblongata have been implicated, the specific pathways associated with autonomic and cardiorespiratory failure are unknown. The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including regulation of respiratory rhythm generation, integration of cardiovascular control, and modulation of the baroreceptor reflex and mediation of the chemorecep..

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University of Melbourne Researchers


Funding Acknowledgements

Study was funded and supported in full by River's Gift SIDS charity Australia, as part of an International SIDS research fellowship awarded to Dr Fiona M Bright, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This work was funded by River's Gift SIDS charity Australia as part of an International SIDS fellowship awarded to FMB. The authors sincerely thank River's Gift for their support. The authors acknowledge Dr. Felicia Tratchenberg, and Ryan Harrison from New England Research Institutes (NERI), Watertown, MA, USA, for assistance with statistical analysis of data and thank the San Diego Medical Examiner system for assistance in the accrual of tissue specimens.