Journal article
Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis
X Bossuyt, JW Cohen Tervaert, Y Arimura, D Blockmans, LF Flores-Suáez, L Guillevin, B Hellmich, D Jayne, JC Jennette, CGM Kallenberg, S Moiseev, P Novikov, A Radice, J Anne Savige, R Alberto Sinico, U Specks, P Van Paassen, MH Zhao, N Rasmussen, J Damoiseaux Show all
Nature Reviews Rheumatology | NATURE PUBLISHING GROUP | Published : 2017
Open access
Abstract
Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increa..
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Funding Acknowledgements
XB has been a consultant for Inova Diagnostics and has received lecture fees from Inova Diagnostics, Menarini and Thermo Fisher. None of the other authors declare a competing interest.