Journal article
Calcitonin receptor expression in medullary thyroid carcinoma
V Cappagli, CS Potes, LB Ferreira, C Tavares, C Eloy, R Elisei, M Sobrinho-Simões, PJ Wookey, P Soares
Peerj | PEERJ INC | Published : 2017
DOI: 10.7717/peerj.3778
Open access
Abstract
Background: Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seventransmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid tumors. The aim of this work was to investigate CTR expression in MTC and to correlate such expression with clinicopathological features in order to evaluate its possible role as a prognostic indicator of disease aggressiveness and outcome. Methods: Calcitonin receptor expression was analyzed in a series of 75 MTCs by immunohistochemistry, and by qPCR mRNA quantification in specimens from four patients. Statistical tests were used to evaluate the ..
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Awarded by Conselho Nacional de Desenvolvimento Científico e Tecnológico
Funding Acknowledgements
This study was supported by ERASMUS+ grant to VC and by Fundacao para a Ciencia e Tecnologia through the post-doctoral grant SFRH/BPD/87537/2012 to CSP and the doctoral grant SFRH/BD/87887/2012 for CT. This study was supported by a CNPq PhD Scholarship ("National Counsel of Technological and Scientific Development", Brazil), Science Without Borders, Process n# 237322/2012-9 for LBF. Further funding from the project "Advancing cancer research: from basic knowledgment to application"; NORTE-01-0145-FEDER-000029; "Projetos Estruturados de I&D&I", funded by Norte 2020 Programa Operacional Regional do Norte; IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT. This work is funded by FEDER funds through the Operational Programme for Competitiveness Factors COMPETE and National Funds through the FCT, under the projects "PEst-C/SAU/LA0003/2013". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.