Journal article

Impact of Lesion Placement on Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation.

Felix Mahfoud, Stefan Tunev, Sebastian Ewen, Bodo Cremers, Jennifer Ruwart, Daniel Schulz-Jander, Dominik Linz, Justin Davies, David E Kandzari, Robert Whitbourn, Michael Böhm, Robert J Melder

Journal of the American College of Cardiology | Published : 2015

Abstract

BACKGROUND: Insufficient procedural efficacy has been proposed to explain nonresponse to renal denervation (RDN). OBJECTIVES: The aim of this study was to examine the impact of different patterns of lesion placements on the efficacy and consistency of catheter-based radiofrequency RDN in pigs. METHODS: The impact of increasing number of lesions versus location of RDN was investigated in a porcine model (Group 1; n = 51). The effect of treating the main artery, the branches, and the 2 combined was compared in Group 2 (n = 48). The durability of response and safety of combined treatment of the main artery plus branches was examined in Group 3 (n = 16). Renal norepinephrine (NE) tissue content ..

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