Journal article

First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension.

Michael Böhm, Felix Mahfoud, Christian Ukena, Uta C Hoppe, Krzysztof Narkiewicz, Manuela Negoita, Luis Ruilope, Markus P Schlaich, Roland E Schmieder, Robert Whitbourn, Bryan Williams, Uwe Zeymer, Andreas Zirlik, Giuseppe Mancia, undefined GSR Investigators

Hypertension | Published : 2015

Abstract

UNLABELLED: This study aimed to assess the safety and effectiveness of renal denervation using the Symplicity system in real-world patients with uncontrolled hypertension (NCT01534299). The Global SYMPLICITY Registry is a prospective, open-label, multicenter registry. Office and 24-hour ambulatory blood pressures (BPs) were measured. Change from baseline to 6 months was analyzed for all patients and for subgroups based on baseline office systolic BP, diabetic status, and renal function; a cohort with severe hypertension (office systolic pressure, ≥160 mm Hg; 24-hour systolic pressure, ≥135 mm Hg; and ≥3 antihypertensive medication classes) was also included. The analysis included protocol-de..

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