Journal article

Expression of parathyroid hormone-related peptide gene in the rat hypothalamus.

RA Fraser, JD Zajac, S Harvey

Comparative Biochemistry and Physiology Part B Comparative Biochemistry | Published : 1993

Abstract

1. Parathyroid hormone-related peptide (PTHrP), originally isolated from human malignant tumors, is present in a variety of normal mammalian tissues, including the brain. 2. The expression and translation of the PTHrP gene within the rat hypothalamus was demonstrated in this study by the specific hybridization of a 1.8 kb mRNA product with a PTHrP cDNA probe and by the crossreactivity of rat hypothalamic extracts in a PTHrP radioimmunoassay. 3. These results suggest roles for PTHrP in neural or hypophysiotropic regulation.

University of Melbourne Researchers