Journal article

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

Chang Tong, Zhinan Yin, Zibo Song, Ashley Dockendorff, Chuanshu Huang, John Mariadason, Richard A Flavell, Roger J Davis, Leonard H Augenlicht, Wancai Yang

American Journal Of Pathology | AMER SOC INVESTIGATIVE PATHOLOGY, INC | Published : 2007


The c-Jun NH(2)-terminal kinase (JNK) signal transduction pathway plays important roles in cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and tumorigenesis is unknown. Therefore, we used a JNK1 knockout mouse model to characterize intestinal cell maturation and tumorigenesis. In addition, colon cancer cell lines were used to validate the role of JNK1 and to elucidate the underlying molecular mechanisms in vitro. To our surprise, we found that mice with targeted inactivation of JNK1 spontaneously developed intestinal tumors. The normal mucosa in JNK1-deficient mice showed decreased cell differentiation and increased cell proliferation. This tumorigenesis wa..

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University of Melbourne Researchers