Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: Implications for targeting Notch signaling

Abstract

Inhibition of Notch signaling is effective in inhibiting colon tumorigenesis, but targeting specific components of the pathway may provide more effective strategies. Here we show that the expression of Jagged1, a ligand for canonical Notch signaling, was restricted to enteroendocrine cells or undetectable in the mucosa of the human small and large intestine, respectively. In contrast, increased expression characterized half of human colon tumors, although not all tumors with elevated Wnt signaling displayed elevated Jagged1. Increased Jagged1 was also present in intestinal tumors of Apc1638N/+ and ApcMin/+ mice, but to a higher level and more frequently in the former, and in 90% of mouse tum..