Intracranial EEG fluctuates over months after implanting electrodes in human brain
Hoameng Ung, Steven N Baldassano, Hank Bink, Abba M Krieger, Shawniqua Williams, Flavia Vitale, Chengyuan Wu, Dean Freestone, Ewan Nurse, Kent Leyde, Kathryn A Davis, Mark Cook, Brian Litt
JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2017
OBJECTIVE: Implanting subdural and penetrating electrodes in the brain causes acute trauma and inflammation that affect intracranial electroencephalographic (iEEG) recordings. This behavior and its potential impact on clinical decision-making and algorithms for implanted devices have not been assessed in detail. In this study we aim to characterize the temporal and spatial variability of continuous, prolonged human iEEG recordings. APPROACH: Intracranial electroencephalography from 15 patients with drug-refractory epilepsy, each implanted with 16 subdural electrodes and continuously monitored for an average of 18 months, was included in this study. Time and spectral domain features were comp..View full abstract
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Awarded by OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
This study was funded by National Institutes of Health (NIH) and the Mirowski Family Foundation grants through the University of Pennsylvania. NIH U01NS073557, T32NS091006, and R01NS099348. The International Epilepsy Electrophysiology Portal is funded by the NIH (U24NS063930).