Journal article

Intracranial EEG fluctuates over months after implanting electrodes in human brain

Hoameng Ung, Steven N Baldassano, Hank Bink, Abba M Krieger, Shawniqua Williams, Flavia Vitale, Chengyuan Wu, Dean Freestone, Ewan Nurse, Kent Leyde, Kathryn A Davis, Mark Cook, Brian Litt

JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2017

Abstract

OBJECTIVE: Implanting subdural and penetrating electrodes in the brain causes acute trauma and inflammation that affect intracranial electroencephalographic (iEEG) recordings. This behavior and its potential impact on clinical decision-making and algorithms for implanted devices have not been assessed in detail. In this study we aim to characterize the temporal and spatial variability of continuous, prolonged human iEEG recordings. APPROACH: Intracranial electroencephalography from 15 patients with drug-refractory epilepsy, each implanted with 16 subdural electrodes and continuously monitored for an average of 18 months, was included in this study. Time and spectral domain features were comp..

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University of Melbourne Researchers