Journal article

Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol

Monica I Alvarez, Luke C Glover, Peter Luo, Liuyang Wang, Elizabeth Theusch, Stefan H Oehlers, Eric M Walton, Thi Bich Tram Trinh, Yu-Lin Kuang, Jerome I Rotter, Colleen M McClean, Tran Chinh Nguyen, Marisa W Medina, David M Tobin, Sarah J Dunstan, Dennis C Ko

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2017

University of Melbourne Researchers

Grants

Awarded by NIH


Awarded by Australian National Health and Medical Research Council CJ Martin Early Career Fellowship


Awarded by Wellcome Trust Major Overseas Program in Viet Nam


Awarded by NIH National Center for Advancing Translational Science University of California, Los Angeles Clinical and Translational Science Institute


Awarded by National Institute of Allergy and Infectious Diseases/NIH


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Awarded by OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH


Funding Acknowledgements

We thank Samuel I. Miller for early support of this work; T. Y. Chang for thoughtful discussions on cholesterol distribution and trafficking; the clinical staff from the Hospital of Tropical Diseases, Ho Chi Minh City, and Dong Thap Provincial Hospital, Vietnam, who initially diagnosed and studied the patients with typhoid fever; and Dr. Nguyen Thi Hieu from Hung Vuong Obstetric Hospital for the collection of the cord blood controls. M.I.A., L.C.G., P.L., L.W., D.M.T., S.J.D., and D.C.K. were supported by NIH Grants R01AI118903 and K22AI093595. D.C.K. was also supported by a Duke University Whitehead Scholarship and the Butler Pioneer Award. M.I.A. is supported by a National Science Foundation Predoctoral Fellowship. L.C.G. was supported by a Duke Molecular Genetics and Microbiology Summer Undergraduate Research Engagement Fellowship. S.H.O. was supported by an Australian National Health and Medical Research Council CJ Martin Early Career Fellowship, Grant 1053407. S.J.D. and T.T.B.T. were supported by the Wellcome Trust Major Overseas Program in Viet Nam, Grant 089276/Z/09/Z. E.T., Y.-L.K., and M.W.M. were supported by NIH Grants U19 HL069757 and P50 GM115318. J.I.R. was supported by NIH National Center for Advancing Translational Science University of California, Los Angeles Clinical and Translational Science Institute Grant UL1TR001881. C.M.M. was supported by National Institute of Allergy and Infectious Diseases/NIH Grant F30 AI126693. The graphical abstract was generated by itFigures Consulting. Research reported in this publication was supported by the Duke Light Microscopy Core and Flow Cytometry Shared Resource. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or other funding sources.