Systematic Mapping of the Subchondral Bone 3D Microarchitecture in the Human Tibial Plateau: Variations With Joint Alignment
Bryant C Roberts, Dominic Thewlis, Lucian B Solomon, Graham Mercer, Karen J Reynolds, Egon Perilli
JOURNAL OF ORTHOPAEDIC RESEARCH | WILEY | Published : 2017
Tibial subchondral bone plays an important role in knee osteoarthritis (OA). Microarchitectural characterization of subchondral bone plate (SBP), underlying subchondral trabecular bone (STB) and relationships between these compartments, however, is limited. The aim of this study was to characterize the spatial distribution of SBP thickness, SBP porosity and STB microarchitecture, and relationships among them, in OA tibiae of varying joint alignment. Twenty-five tibial plateaus from end-stage knee-OA patients, with varus (n = 17) or non-varus (n = 8) alignment were micro-CT scanned (17 μm/voxel). SBP and STB microarchitecture was quantified via a systematic mapping in 22 volumes of interest p..View full abstract
Grant in Aid (2013), Arthritis Australia-Zimmer Australia; Grant sponsor: Catalyst Grant DSD (2013), Premier's Research and Industry Fund, Government of South Australia.