Interleukin-18 is Crucial for the Development of Renal Inflammation and Elevated Blood Pressure in a Mouse Model of Hypertension

Yeong Hann Ling; Jordyn Thomas; Shalini Murali Krishnan; Dorota Ferens; Seth Masters; Barbara Kemp-Harper; Ashley Mansell; Christopher Sobey; Grant Drummond

Conference Proceedings

Interleukin-18 is Crucial for the Development of Renal Inflammation and Elevated Blood Pressure in a Mouse Model of Hypertension

Yeong Hann Ling, Jordyn Thomas, Shalini Murali Krishnan, Dorota Ferens, Seth Masters, Barbara Kemp-Harper, Ashley Mansell, Christopher Sobey, Grant Drummond

FASEB JOURNAL | FEDERATION AMER SOC EXP BIOL | Published : 2017

DOI: 10.1096/fasebj.31.1_supplement.998.1

Abstract

Background Interleukin‐18 (IL‐18) is a cytokine released downstream of inflammasome activation that promotes pro‐inflammatory T H 1 immune responses. Clinical studies have shown that levels of IL‐18 are elevated in hypertensive patients. However, whether IL‐18 plays a causal role in hypertension is unknown. Aims To determine if IL‐18 and/or its receptor (IL‐18R) are upregulated in kidneys of hypertensive mice and to establish if IL‐18 deficiency protects mice against the development of hypertension and renal ..

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