Journal article

Amyloid-beta-peptide reduces copper(II) to copper(I) independent of its aggregation state

C Opazo, FH Ruiz, NC Inestrosa

BIOLOGICAL RESEARCH | SOCIEDAD BIOLGIA CHILE | Published : 2000

Abstract

Alzheimer's disease (AD) is characterized by the deposition of amyloid beta-peptide (A beta) and neuronal degeneration in brain regions involved in learning and memory. One of the leading etiologic hypotheses regarding AD is the involvement of free radical-mediated oxidative stress in neuronal degeneration. Recent evidence suggests that metals concentrated in amyloid deposits may contribute to the oxidative insults observed in AD-affected brains. We hypothesized that A beta peptide in the presence of copper enhances its neurotoxicity generating free radicals via copper reduction. In the present study, we have examined the effect of the aggregation state of amyloid-beta-peptide on copper redu..

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