Validation of a Portable Low-Power Deep Brain Stimulation Device Through Anxiolytic Effects in a Laboratory Rat Model
Abbas Z Kouzani, Rajas P Kale, Pablo Patricio Zarate-Garza, Michael Berk, Ken Walder, Susannah J Tye
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2017
Deep brain stimulation (DBS) devices deliver electrical pulses to neural tissue through an electrode. To study the mechanisms and therapeutic benefits of deep brain stimulation, murine preclinical research is necessary. However, conducting naturalistic long-term, uninterrupted animal behavioral experiments can be difficult with bench-top systems. The reduction of size, weight, power consumption, and cost of DBS devices can assist the progress of this research in animal studies. A low power, low weight, miniature DBS device is presented in this paper. This device consists of electronic hardware and software components including a low-power microcontroller, an adjustable current source, an n-c..View full abstract
Awarded by NHMRC Senior Principal Research Fellowship
The work of M. Berk was supported by a NHMRC Senior Principal Research Fellowship under Grant 1059660.