Journal article

Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes

Melissa S DeRycke, Shanaka Gunawardena, Jessica R Balcom, Angela M Pickart, Lindsey A Waltman, Amy J French, Shannon McDonnell, Shaun M Riska, Zachary C Fogarty, Melissa C Larson, Sumit Middha, Bruce W Eckloff, Yan W Asmann, Matthew J Ferber, Robert W Haile, Steven Gallinger, Mark Clendenning, Christophe Rosty, Aung K Win, Daniel D Buchanan Show all

MOLECULAR GENETICS & GENOMIC MEDICINE | WILEY | Published : 2017

Abstract

BACKGROUND: Mutations in several genes predispose to colorectal cancer. Genetic testing for hereditary colorectal cancer syndromes was previously limited to single gene tests; thus, only a very limited number of genes were tested, and rarely those infrequently mutated in colorectal cancer. Next-generation sequencing technologies have made it possible to sequencing panels of genes known and suspected to influence colorectal cancer susceptibility. METHODS: Targeted sequencing of 36 known or putative CRC susceptibility genes was conducted for 1231 CRC cases from five subsets: (1) Familial Colorectal Cancer Type X (n = 153); (2) CRC unselected by tumor immunohistochemical or microsatellite stabi..

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Grants

Awarded by National Cancer Institute


Awarded by Hawai'i Department of Health


Awarded by California Department of Public Health


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

National Cancer Institute (Grant/Award Number: 'CA074778', 'CA074783', 'CA074794', 'CA074799', 'CA074800', 'CA074806', 'CA097735', 'CA104132', 'CA167551', 'HHSN2612013000121', 'N01-CN-67009', 'N01-PC-35142'), Hawai'i Department of Health (Grant/Award Number: 'HHSN26120100037C', 'N01-PC-35137', 'N01-PC-67001'), and California Department of Public Health (Grant/Award Number: 'HHSN261201000035C', 'HHSN261201000140C').